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In November 333 BC, the Macedonian troops led by Alexander the Great, outnumbered roughly by four to one, defeated the army led by Darius III of Persia in the Battle of Issus. 公元前三三三年十一月， 亚历山大大帝率领马其顿部队， 大约以一敌四， 击败大流士三世统领的波斯军。